TCT-168 Vessel Remodeling Mechanisms After Bioresorbable Scaffold Implantation

The Return of Coronary Vasomotion After Bioresorbable Scaffold Implantation.

T he coronary artery endothelial lining maintains vascular tone and regulates blood flow. Mechanical forces such as increased shear stress trigger activation of endothelial cells, prompting generation of nitric oxide (NO) and prostacyclin, which promote vasodilation and increased flow. NO causes relaxation of vascular smooth muscle cells as well as inhibition of smooth muscle cell proliferation...

Vascular Healing of a False Lumen After Bioresorbable Scaffold Implantation.

Bioresorbable scaffolds (BRS) are promising devices for the treatment of coronary artery disease by virtue of their resorption properties allowing positive vascular remodeling. This case report illustrates the vascular healing process after Absorb BRS (Abbott Vascular, Santa Clara, CA) implantation in a false lumen during the treatment of a chronic total occlusion. A 62-year-old male with stabl...

Coronary Artery Vessel Healing Pattern, Short and Long Term, After Implantation of the Everolimus‐Eluting Bioresorbable Vascular Scaffold

BACKGROUND Although the Absorb bioresorbable vascular scaffold is increasingly used in daily clinical practice for the treatment of coronary artery disease, the exact vascular healing pattern and the resorption process in humans is unknown because histological data are derived only from animal studies. METHODS AND RESULTS We have obtained 4 autopsies (5 scaffolds) since August 2013. Duration ...

Fate of Bioresorbable Vascular Scaffold Metallic Radio-Opaque Markers at the Site of Implantation After Bioresorption.

revascularization are needed. We also agree with Conti’s opinion that, unless ischemia is present, collaterals do not appear angiographically; if the collateral provides excellent blood flow to ischemic myocardium, the collaterals will remain (2). Werner et al. (3) reported that even collaterals that appear well developed on angiography are not able to fully replace anterograde blood flow; ther...

Neointimal proliferation is associated with clinical restenosis 2 years after fully bioresorbable vascular scaffold implantation.